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An Overview of Invirase (Saquinavir Mesylate)

May 11, 2015

Invirase 500mg PillSaquinavir 0245

Brand Name: Invirase
Other Names: saquinavir mesylate, SQV
Drug Class: Protease Inhibitors
Approved Use: Treatment of HIV Infection


Chemical Image

saquinavir mesylate chemical image

saquinavir mesylate
Molecular Weight: 766.956


WARNING:

Saquinavir can cause serious, life-threatening side effects. These include heart rhythm problems and worsening liver problems in people with pre-existing liver problems or a history of alcoholism.

Contact your health care provider right away if you have any of the following symptoms that could be signs of heart rhythm problems:

Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:

Taking saquinavir together with certain medicines can cause serious and/or life-threatening side effects.

While taking saquinavir, it is important to keep all of your appointments with your health care provider.


What Is Saquinavir?

Saquinavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in people 16 years of age and older. Saquinavir is always used in combination with the HIV medicine ritonavir (brand name: Norvir) and other HIV medicines.

Saquinavir belongs to a class (group) of HIV drugs called protease inhibitors (PIs). PIs block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including saquinavir, don't cut down on, skip, or stop taking them unless your health care provider tells you to.


What Should I Tell My Health Care Provider Before Taking Saquinavir?

Before taking saquinavir, tell your health care provider:


How Should I Take Saquinavir?

Saquinavir comes in the following forms and strengths, under the brand name Invirase:

(A 200-mg soft-gel capsule form of saquinavir was formerly sold under the brand name Fortovase. Sale of Fortovase was discontinued in February 2006.)

Take saquinavir according to your health care provider's instructions.

Take saquinavir at the same time that you take the HIV medicine ritonavir (brand name: Norvir). Take saquinavir, along with ritonavir, with a full meal or up to 2 hours after a meal.

Always take saquinavir in combination with other HIV medicines.

If you are unable to swallow saquinavir capsules whole, the capsules can be opened and the contents mixed with 15 mL of sugar syrup or jam. People with type 1 diabetes or glucose intolerance should use sorbitol syrup.

If you take too much saquinavir, contact your health care provider or local poison control center (1-800-222-1222) right away or go to the nearest hospital emergency room.

For more information on how to take saquinavir, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)


What Should I Do if I Forget a Dose?

If you miss a dose of saquinavir, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.


What Side Effects Can Saquinavir Cause?

Saquinavir can cause serious, life-threatening side effects. These include heart rhythm problems and worsening liver problems in people with pre-existing liver problems or a history of alcoholism. (See the WARNING above.)

Other possible side effects of saquinavir include:

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of saquinavir. To learn more about possible side effects of saquinavir, read the drug label or package insert or talk to your health care provider or pharmacist.

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to saquinavir.

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.


How Should Saquinavir Be Stored?


Where Can I Find More Information About Saquinavir?

More information about saquinavir is available:


Manufacturer Information

Hoffman-La Roche
888-835-2555

The above Patient Version drug summary is based on the following FDA label(s): Capsule, tablet (film coated).




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