An Overview of Atripla (Efavirenz/Tenofovir/FTC)
August 1, 2018
Brand Name: Atripla
Atripla can cause serious, life-threatening side effects. These include buildup of lactic acid in the blood (lactic acidosis) and liver problems.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
Atripla can cause new or worsening liver problems. Contact your health care provider right away if you have any of the following symptoms that may be signs of liver problems:
Atripla is not approved for the treatment of chronic hepatitis B virus infection (HBV). If you have both HIV and HBV and take Atripla, your HBV may get much worse (flare up) if you stop taking Atripla. The HBV drug adefovir dipivoxil (brand name: Hepsera) should not be taken with Atripla.
If you take Atripla, you should not take certain other HIV medicines. Atripla may interact with some drugs, which can cause serious or life-threatening side effects.
While taking Atripla, it is important to keep all of your appointments with your health care provider.
What Is Atripla?
Atripla is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 12 years of age and older who weigh at least 88 pounds (40 kg). Atripla can be used alone as a complete treatment regimen or with other HIV medicines.
Atripla contains the following three different HIV medicines combined in one pill:
Both NNRTIs and NRTIs block an HIV enzyme called reverse transcriptase. By blocking reverse transcriptase, the three drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
What Should I Tell My Health Care Provider Before Taking Atripla?
Before taking Atripla, tell your health care provider:
How Should I Take Atripla?
Atripla comes in tablet form. Each tablet contains:
Take Atripla according to your health care provider's instructions.
Take Atripla on an empty stomach, preferably at bedtime. Swallow Atripla tablets with water.
If you take too much Atripla, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Atripla, see the FDA drug label.
What Should I Do if I Forget a Dose?
If you miss a dose of Atripla, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What Side Effects Can Atripla Cause?
Atripla may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Atripla can be serious. Serious side effects of Atripla include buildup of lactic acid in the blood (lactic acidosis) and liver problems. (See the WARNING box above.)
Other possible side effects of Atripla include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Atripla. To learn more about possible side effects of Atripla, read the drug label or package insert or talk to your health care provider or pharmacist.
You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How Should Atripla Be Stored?
Where Can I Find More Information About Atripla?
More information about Atripla is available:
Gilead Sciences, Inc.
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
[Note from TheBody: This article was created by AIDSinfo, who last updated it on July 16, 2018. We have cross-posted it with their permission.]
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
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