An Overview of Isentress (Raltegravir)
August 29, 2018
Brand Name: Isentress
Raltegravir can cause serious, life-threatening side effects. These include skin reactions, allergic reactions, and liver problems.
Stop taking raltegravir and contact your health care provider right away if you develop a rash with any of the following symptoms:
An allergic reaction to raltegravir can cause liver problems. Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
While taking raltegravir, it is important to keep all of your appointments with your health care provider.
What Is Raltegravir?
Raltegravir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children. One form of raltegravir, Isentress, is approved for all adults and children weighing at least 4 pounds and 4 ounces (2 kilograms). Another form of raltegravir, Isentress HD, is approved for all adults and children weighing at least 88 pounds (40 kilograms). Raltegravir is always used in combination with other HIV medicines.
Raltegravir belongs to a group of HIV drugs called integrase inhibitors. Integrase inhibitors block an HIV enzyme, a type of protein, called integrase. By blocking integrase, integrase inhibitors prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
What Should I Tell My Health Care Provider Before Taking Raltegravir?
Before taking raltegravir, tell your health care provider:
How Should I Take Raltegravir?
Raltegravir comes in the following forms and strengths::
Take raltegravir according to your health care provider's instructions.
Take raltegravir by mouth, with or without food. Always swallow the film-coated tablets whole. The chewable tablets may be chewed or swallowed whole.
Raltegravir for oral suspension must be mixed with water before use and given within 30 minutes of mixing. Raltegravir for oral suspension comes in a kit that contains the packets of raltegravir and reusable syringes and cups needed to mix and give the medicine. See the detailed instructions that come with the kit for information about the correct way to mix and give a dose of raltegravir for oral suspension. If you have questions about how to mix or give raltegravir for oral suspension, talk to your health care provider or pharmacist.
Do not switch between the film-coated tablets, the chewable tablets, or the oral suspension without talking with your health care provider first.
Always take raltegravir in combination with other HIV medicines.
If you take too much raltegravir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take raltegravir, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
What Should I Do if I Forget a Dose?
If you miss a dose of raltegravir, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What Side Effects Can Raltegravir Cause?
Raltegravir may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of raltegravir can be serious. Serious side effects of raltegravir include skin reactions, allergic reactions, and liver problems. (See the WARNING box above.)
Other possible side effects of raltegravir include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of raltegravir. To learn more about possible side effects of raltegravir, read the drug label or package insert or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online.
How Should Raltegravir Be Stored?
Where Can I Find More Information About Raltegravir?
More information about raltegravir is available:
Merck & Co., Inc.
The above Patient Version drug summary is based on the following FDA label(s): Tablet (chewable), tablet (film coated), granule for oral suspension.
[Note from TheBody.com: This article was created by AIDSinfo, who last updated it on Aug. 1, 2018. We have cross-posted it with their permission.]
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
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