HIV Coinfections

What is a coinfection?

Coinfection means infection with more than one disease at the same time. Some coinfections commonly seen in people infected with HIV include:

• Hepatitis B virus (HBV)/HIV coinfection
• Hepatitis C virus (HCV)/HIV coinfection
• Tuberculosis (TB)/HIV coinfection

People infected with HIV should be tested for HBV, HCV, and TB.

What are HBV and HCV?

HBV and HCV are two different viruses that both cause liver disease. They are also among the most common causes of liver cancer.

HBV is spread through the blood, semen, or other body fluid of an HBV-infected person. Having unprotected sex or sharing drug needles with a person infected with HBV are the main ways people get HBV. (To prevent HBV infection, people infected with HIV may consider getting the HBV vaccination.)

HCV is spread through the blood of a person infected with HCV. Sharing drug needles with a person with HCV is the main way people get HCV; however, HCV can also be transmitted during unprotected sex.

Having unprotected sex or sharing drug needles are also ways people get HIV. That is why some people become coinfected with HIV and HBV or HCV (or both) at the same time.

What is TB?

TB is a disease caused by germs that spread through the air when a person with active TB coughs, sneezes, or talks. TB usually affects the lungs.

There are two forms of TB: latent TB infection and TB disease. Latent TB infection is the inactive form of TB. The TB germs in the body are "sleeping" and don't make the person sick. A person with latent TB infection can't spread TB to others.

Without treatment, latent TB infection may advance to TB disease, especially in people with weakened immune systems. The TB germs in the body multiply and become active, making the person sick. A person with TB disease of the lungs can spread TB to others.

Because HIV weakens the immune system, latent TB infection is more likely to advance to TB disease in a person with HIV. In a person infected with HIV, TB disease is considered an AIDS-defining condition, and TB treatment should be started immediately.

Are coinfections more serious in people infected with HIV?

Yes. Coinfections may become serious more rapidly in people infected with HIV.

HBV and HCV both lead to liver damage more quickly in people infected with HIV. People co-infected with HBV or HCV also have a higher risk of developing liver damage from anti-HIV medications.

And TB disease can cause HIV infection to advance more rapidly, putting the person at risk of opportunistic infections.

Can coinfections be treated?

Yes; however, the effectiveness of treatment depends on the coinfection.

• TB treatment can cure TB disease or prevent latent TB infection from advancing to TB disease.
• Although there is no cure for HBV, treatment can slow down HBV infection.
• Treatment for HCV is generally less effective.

Are HIV and coinfections treated at the same time?

Yes, however, what medications to take and when to start them depend on the coinfection. Some anti-HIV medications are effective against both HIV and HBV. Treatment for HCV or TB involves taking other medications in addition to anti-HIV medications.

When treating coinfections, health care providers closely watch for any side effects or drug interactions between anti-HIV medications and medications used to treat coinfections.

Talk to your health care provider if you have questions about HIV and coinfections.

For More Information

Contact an AIDSinfo health information specialist at 1–800–448–0440 or visit http://aidsinfo.nih.gov. See your health care provider for medical advice.

This information is based on the U.S. Department of Health and Human Services' Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents (available at http://aidsinfo.nih.gov/Guidelines/).