Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: TheBodyPRO.com Covers AIDS 2014

HIV Life >> Living With HIV

Blixer
Legend

Reged: 01/10/06
Posts: 599
Loc: Missouri
Re: Drug Holidays may be over for HIV patients.
      12/04/06 07:24 PM

Even though the SMART study is a very important one and was stopped very early on because of the significant issues, it had parameters that set the "holliday" at a CD4 count of around 350 and the restart at a CD4 count of around 200 or so. The study demonstrated that those parameters definately don't work for treatment interruptions. But there have been some much smaller studies that set the limits much higher... for instance in one, I believe the starting point was like 500 or above and the restart point was like 350. The results from that study were not nearly as dismal as the SMART study. It was too small to really draw any conclusions but it may be that starting with a less damaged immune system could allow for drug holidays. Lots of area for cautious research with those different parameters. And of course, everyone's body tends to react differently. Just some thoughts.

Here is a quote from an article posted on Aidsmeds about the whole situation: "It is important to note, however, that other studies evaluating treatment interruptions of this nature have reported more encouraging results. In the August 5 edition of The Lancet, for example, the STACCATO trial found that treatment interruptions reduced the risk of side effects compared to those on continuous treatment. The study, enrolling 430 HIV-positive patients, used a CD4 count of 350 to signal the restart of treatment, which differs significantly from SMART's 250 CD4 cell count cutoff."

It discusses the SMART study and some of the other parameters. Here is the link to the entire article. http://www.aidsmeds.com/news/am20061130.html

--------------------
David
Sustiva, Epivir, Videx EC


Post Extras: Remind Me!     Notify Moderator

Entire thread
Subject Posted by Posted on
* Drug Holidays may be over for HIV patients. sunkyst 12/01/06 10:06 PM
. * Re: Drug Holidays may be over for HIV patients. Shelley   12/06/06 12:53 PM
. * Re: Drug Holidays may be over for HIV patients. ScotCharles   12/05/06 11:03 AM
. * Re: Drug Holidays may be over for HIV patients. alivehoping   12/06/06 09:09 AM
. * Re: Drug Holidays may be over for HIV patients. ScotCharles   12/06/06 12:05 PM
. * Re: Drug Holidays may be over for HIV patients. alivehoping   12/07/06 01:27 AM
. * Re: Drug Holidays may be over for HIV patients. ScotCharles   12/08/06 10:37 AM
. * Re: Drug Holidays may be over for HIV patients. alivehoping   12/08/06 11:23 AM
. * Re: Drug Holidays may be over for HIV patients. Blixer   12/05/06 11:06 PM
. * Re: Drug Holidays may be over for HIV patients. ScotCharles   12/06/06 12:10 PM
. * Re: Drug Holidays may be over for HIV patients. alivehoping   12/08/06 03:02 AM
. * Re: Drug Holidays may be over for HIV patients. Blixer   12/04/06 07:24 PM
. * Re: Drug Holidays may be over for HIV patients. alivehoping   12/05/06 02:35 AM
. * Re: Drug Holidays may be over for HIV patients. antibody   12/12/06 07:16 PM
. * Re: Drug Holidays may be over for HIV patients. ScotCharles   12/13/06 11:05 AM

What's New at TheBody.com

Additional Information
0 registered and 0 anonymous users are browsing this forum.

Moderator:  TheBody, bogart, crabman, riverprincess 



Permissions
      You cannot start new topics
      You cannot reply to topics
      HTML is enabled
      UBBCode is enabled

Thread views: 6446

Jump to

Contact Us | Privacy Statement The Body

*
UBB.threads™ 6.2.3