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HIV Transmission and Education >> Am I Infected?

KitG
Expert

Reged: 01/15/01
Posts: 103
Re: Risk of Catching HIV in Single Sex Act Low
      02/09/01 09:35 AM

Interesting info.

I suppose the more studies take place, the more accurate the single sexual encounter risk will be. One in 588 now and interesting to see that the female-to-male transmission rate is higher than male-to-female (albeit insignificantly).
Admittedly, this is just one study but it goes against previous assumptions.

Also going against previous assumptions is the article I've posted below, which appeared on the British HIV Association last October, and which cites "single contact studies in commercial sex workers which have shown transmission rates of 3.1% - 8.2% from women to men, and rates in excess of 50% per episode in men to women".

This percentage game is wild! I sat down and worked out my risk (one-off encounter, condom break, partner of unknown HIV status, post-six-month seroconversion) as being anywhere between 0.0000001 and 0.000000000001. Which was enough to make me start looking for explanations other than HIV infection.

Speaking of which, I was also very interested to read that "several studies in commercial sex workers and other individuals repeatedly exposed to HIV have shown that HIV-specific cytotoxic T-lymphocyte responses to HIV are detectable in these individuals, despite no evidence of HIV infection". Does anyone have any info on this? I've had a bit of a search but come up with nothing. I'm just wondering whether there is any symptomatological association with this response.


Full article for anyone who's interested.


aidsmap news archive:
HIV risk from single contact may be higher than thought


Posted: Tuesday October 24 2000
by Keith Alcorn, editor, aidsmap.com
http://www.aidsmap.com/

The risk of HIV transmission from activities like unprotected anal intercourse with new partners may be dangerously underestimated by long-term studies of serodiscordant partners, a leading researcher into the sexual transmission of HIV said today.

Speaking at the Fifth International Congress on Drug Therapy in HIV Infection, Dr Pietro Vernazza of the Cantonal Hospital, St Gallen, Switzerland, said:

“We’re citing these studies all the time, but I think it’s time we re-considered other data”.

Although long-term partner studies have shown that the risk of male to female or female to male transmission from a single episode of sexual intercourse may be as little as 0.3%, Vernazza points to single contact studies in commercial sex workers which have shown transmission rates of 3.1% - 8.2% from women to men, and rates in excess of 50% per episode in men to women.

He argues that long-term partner studies do not factor in the protective effect of any HIV-specific immunity that develops in partners who are repeatedly exposed to HIV but remain uninfected. Several studies in commercial sex workers and other individuals repeatedly exposed to HIV have shown that HIV-specific cytotoxic T-lymphocyte responses to HIV are detectable in these individuals, despite no evidence of HIV infection.

“The highest risk of transmission probably lies in the first few contacts” said Pietro Vernazza.

Risk of transmission during structured treatment interruptions

Vernazza also presented a case history which is likely to have a strong influence on advice about structured treatment interruptions – a case of sexual transmission during an STI by a man with previously undetectable viral load.

The man, who had had undetectable viral load prior to the treatment interruption, had been having unprotected sexual intercourse with his female partner prior to the STI. Two weeks after the STI, his female partner reported an acute viral illness, and tests revealed that she had become infected with HIV.



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Subject Posted by Posted on
* Risk of Catching HIV in Single Sex Act Low Anon_E_Moose 02/09/01 07:40 AM
. * Re: Risk of Catching HIV in Single Sex Act Low KitG   02/09/01 09:35 AM
. * Re: Risk of Catching HIV in Single Sex Act Low Anonymous   02/09/01 11:59 AM

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