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Reged: 05/24/07
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some one with more knowledge please explain this
      #252635 - 10/22/10 02:52 PM

Does this mean they cured HIV in these patents?
Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF).

Yamamoto N, Ushijima N, Koga Y.

Division of Molecular Immunology and Immunotherapy, Socrates Institute for Therapeutic Immunology, Philadelphia, Pennsylvania 19126-3305, USA.

Serum Gc protein (known as vitamin D3-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIV-infected patients was lost or reduced because Gc protein is deglycosylated by alpha-N-acetylgalactosaminidase (Nagalase) secreted from HIV-infected cells. Therefore, macrophages of HIV-infected patients having deglycosylated Gc protein cannot be activated, leading to immunosuppression. Since Nagalase is the intrinsic component of the envelope protein gp120, serum Nagalase activity is the sum of enzyme activities carried by both HIV virions and envelope proteins. These Nagalase carriers were already complexed with anti-HIV immunoglobulin G (IgG) but retained Nagalase activity that is required for infectivity. Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent macrophage activating factor (termed GcMAF), which produces no side effects in humans. Macrophages activated by administration of 100 ng GcMAF develop a large amount of Fc-receptors as well as an enormous variation of receptors that recognize IgG-bound and unbound HIV virions. Since latently HIV-infected cells are unstable and constantly release HIV virions, the activated macrophages rapidly intercept the released HIV virions to prevent reinfection resulting in exhaustion of infected cells. After less than 18 weekly administrations of 100 ng GcMAF for nonanemic patients, they exhibited low serum Nagalase activities equivalent to healthy controls, indicating eradication of HIV-infection, which was also confirmed by no infectious center formation by provirus inducing agent-treated patient PBMCs. No recurrence occurred and their healthy CD + cell counts were maintained for 7 years.

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Reged: 01/19/10
Posts: 660
Re: some one with more knowledge please explain this new
      #252649 - 10/22/10 09:49 PM

well that's just confusing. i had to reread it a couple of times. i also looked more into it and most people are saying it's too early to tell if this will lead anywhere. the study size was about 15 people and Nagalase isn't a clear marker of HIV.

also, found this letter from another forum:

This is in reply to your inquiry dated January 8, 2009, to the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), concerning an article reported in the January 2009 issue of the Journal of Virology.

While the report of this immunotherapeutic intervention is very interesting and very important, it is early to know whether GcMAF can actually eradicate HIV. Further research, using modern plasma viral load assays, would be important in determining the significance of this treatment.

That said, harnessing the power of the immune system could be a very potent way to treat HIV infection. A number of strategies are being investigated to suppress the virus and enhance resistance to HIV. NIAID will continue to support the fundamental research that will be the foundation for new therapeutic approaches to HIV/AIDS.

We hope this information will be helpful to you.


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