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Reged: 03/05/07
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Scientists Identify Gene That Blocks HIV
      #237063 - 02/29/08 11:37 PM

Is this a good thing?

Scientists Identify Gene That Blocks HIV

American and Canadian researchers have identified a human gene called TRIM22 that can block HIV infection by preventing certain forms of the virus from replicating, CBC News reported.

In laboratory tests, the scientists found that cells in which TRIM22 was switched off couldn't defend themselves against HIV, the virus that causes AIDS.

"This means that TRIM22 is an essential part of our body's ability to fight off HIV," Dr. Stephen Barr, a researcher in the department of medical microbiology and immunology at the University of Alberta in Edmonton, said in a prepared statement.

The study was published in the Public Library of Science journal Pathogens. Previous research had found that other genes in the TRIM family could prevent certain forms of HIV viruses from replicating, CBC News reported.

Barr and his colleagues are now investigating how TRIM22 can be switched on in people who can't defend themselves against HIV.

"We hope that our research will lead to the design of new drugs and/or vaccines that can halt the person-to-person transmission of HIV and the spread of the virus in the body, thereby blocking the onset of AIDS," said Barr, who added that this type of achievement could take decades.

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Reged: 01/20/07
Posts: 1186
Re: Scientists Identify Gene That Blocks HIV new
      #237068 - 03/01/08 07:50 AM

Any step forward is a good thing.

Here is another article that came out yesterday about the research being done.

Asian monkey gene that blocks HIV found

Fri, Feb 29 10:11 AM

Washington, Feb 29 (IANS) A gene in Asian monkeys that may have evolved as a defence against lentiviruses, the group that includes HIV, has been identified by Harvard Medical School researchers.

The gene, TRIM5-CypA, is a hybrid of two existing genes, TRIM5 and CypA. The combination produces a single protein capable of blocking infection by viruses closely related to HIV.

This is actually the second time researchers have identified a TRIM5-CypA gene in monkeys. The other hybrid, called TRIMCyp, was discovered in 2004 in South American owl monkeys.

Normally, evolutionary biologists assume that similar DNA sequences, present in the same location in the genomes of two or more species, evolved only once.

In this scenario, the gene arises first in a common ancestor and is subsequently inherited by all the species that descend from that ancestor. In the case of TRIM5-CypA and TRIMCyp, this does not appear to be the case.

TRIM5-CypA was not found in monkeys closely related to the Asian macaques, and in fact, was not found in every macaque individual tested.

Likewise, owl monkey TRIMCyp was not found in any other species of South American primate. Researchers suggest that the two genes arose independently, once each in owl monkeys and macaques.

More tellingly, even though the protein sequences specified by two TRIM5-CypA genes are similar, at the DNA level it is obvious that the molecular events leading to formation of the two genes were different.

Evolutionary biologists refer to the acquisition of a similar adaptation in different species as 'convergent evolution', an example being the independent appearance of flight in both birds and bats.

The Harvard team's genetic evidence indicates that the two TRIM5-CypA genes constitute an unambiguous and particularly striking example of convergent evolution.

That the process occurred at least twice during primate evolution suggests that the combination of the TRIM5 and CypA genes provided a strong evolutionary advantage to the individuals in which they originally appeared.

The study has been published in the latest issue of journal PLoS Pathogens, suggesting that AIDS is not a new epidemic.

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