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HIV Life >> Living With HIV

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Anonymous
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Major Strategic Breakthrough
      #204629 - 08/23/06 05:09 PM

Major Strategic Breakthrough In Controlling The AIDS Virus Made By Montreal Researchers

23 Aug 2006

http://www.medicalnewstoday.com/medicalnews.php?newsid=50180

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A team of researchers from the Universite de Montreal and the Centre hospitalier de l'Universite de Montreal (CHUM) have announced an important breakthrough in fighting the human immunodeficiency virus (HIV). For the first time, scientists have identified a defect in the immune response to HIV and found a way to correct the flaw. Dr. Rafick-Pierre Sekaly, an eminent researcher in cell biology, immunology, and virology, has confirmed the identification of a new therapeutic target (the PD-1 protein) that restores the function of the T cells whose role is to eliminate cells infected with the virus. This constitutes a major breakthrough, opening new prospects for the development of therapeutic strategies for controlling HIV infection. The research findings appear in today's issue of the journal Nature Medicine.



Dr. Sekaly explained that "immune system cells made non-functional by HIV can be identified by the presence of a protein that is significantly overexpressed when infected by the virus." In fact, high levels of the protein are associated with a more serious dysfunction. "The most important discovery made in this study arises from the fact that by stimulating this protein, we succeeded in preventing the virus from making immune system cells dysfunctional," he added.



The findings were simultaneously reproduced by two other laboratories - the labs headed by Dr. Bruce Walker at Harvard and Dr. Richard Koup at the NIH.

"It's a rare occurrence for three teams to work together on attacking a major problem. Up until now, the virus has been more or less invincible. By combining our efforts, we found the missing link that may enable us to defeat the virus," noted Dr. Sekaly. Discussions with partners are also underway to translate these research findings into clinical trials, which could start during the coming year.



Thanks to the joint efforts of the Universite de Montreal, the CHUM Research Centre, Genome Quebec, Genome Canada, the Canadian Institutes of Health Research (CIHR), the Canada Foundation for Innovation, the NIH, and the Fonds de la recherche en sante du Quebec (FRSQ), Quebec continues to show great leadership in the life sciences.



Paul L'Archeveque and Martin Godbout, the presidents of Genome Quebec and Genome Canada respectively, saluted the vision of the research team and the importance for Quebec and Canada of continuing to invest in genomics research. "The $14 million invested in this project certainly played a role in accelerating the researchers' work, and in helping Montreal to remain competitive on the international scene," noted the agency heads, adding that Dr. Sekaly's team was the first in the world to present the findings of this major study.



"The results of Dr. Sekaly's study represent an important step in the development of a new therapeutic approach in the fight against HIV," said Dr. Alan Bernstein, CIHR President. "This study is a compelling example of the excellence of Canadian health researchers and of Canada's contribution to the world's response to the HIV-AIDS pandemic."



"This important discovery is a powerful example of what can be achieved through partnership," added Dr. Eliot Phillipson, President and CEO of the Canada Foundation for Innovation. "Canada is proud to have researchers of Dr. Sekaly's calibre keeping our country at the forefront of the global fight against HIV-AIDS."



Dr. Mark Wainberg, Co-Director of the FRSQ-AIDS and infectious diseases Network and Co-Chair of the 16th World AIDS Conference held in Toronto last week, congratulated Dr. Sekaly and his team: "This scientific breakthrough is a giant step in the fight against AIDS. It is particularly interesting to see that some of the best research teams are working together to stop this terrible curse."



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Survivor
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Re: Major Strategic Breakthrough new
      #204834 - 08/24/06 09:14 PM

I hope everyone realizes how big a deal this actually is!

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alivehoping
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Re: Major Strategic Breakthrough new
      #204907 - 08/25/06 10:19 AM

eric,is this real?or is it another snake oil deal?so many of the nature "cures" are displayed on this site at times,i cant really beleive this is true,could this be real,if it is hopfully it will begin to help scientist do something to get things rolling faster for those who are in dire need before it to late.thanks take care

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Survivor
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Reged: 10/30/05
Posts: 3256
Loc: Get off the fence and live again!
Re: Major Strategic Breakthrough new
      #204977 - 08/25/06 10:47 PM

Oh this is quite real.. This is like as big as when they identified the virus itself back in the earily 80's. Now they know that our cd4's are not destroyed, they are just deactivated.. They have found the gene that has to be switched back on and have done this in the labratory...

HUGE!!!

Eric

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Anonymous
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Re: Major Strategic Breakthrough new
      #205110 - 08/27/06 06:03 PM

ya, the fact that 3 reputable labs (especially Harvard and NIH) took interest in this, probably means they see some serious potential

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alivehoping
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Re: Major Strategic Breakthrough new
      #205137 - 08/27/06 11:45 PM

dont this go to show you canadians are working harder and more efficient to do what needs to be done,versus the american phams all keeping everyone suffering and by doing this profit in unimaginable ways. the canadians are willing to work together as a team,go habs

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