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STI Test
      #16243 - 03/06/01 10:04 PM

Page 36 of

Julianna Lisziewicz, PhD
RIGHT Institute, Washington, D.C.

An experimental assay to quantify HIV-1 Virus-specific Immune Response (VIR) mimics viral rebound in vitro then measures IFN-gamma expression of CD4+ and CD8+ cells. VIR correlates well with treated, untreated and intermittently treated patients in cases when viral load and CD4+ count do not. In SIV 251 infected macaques, VIR is absent when viremia is controlled by HAART and VIR is present when STI is performed.

The "Washington Patient" was treated then had five interruptions with an in-creasing duration off drug. VIR increased with each successive interruption from 2% to 5.7%. CD4+ and C8+ cell counts did not correlate with the interruptions. VIR detects functional (perforin producing) CD8+ cells and correlates with the duration of immune control.

· VIR determines the absolute number and percentage of functional HIV-1 specific T-cells.

· The quantity of VIR correlates with the duration of immune control of HIV-1

· VIR detects functional HIV-1-specific CTL

· VIR analyzes IFN-gamma production by T-cell subsets (CD4/CD8)

· VIR does not depend on HLA or peptides (unlike tetramers)

· Small samples are sufficient (10mL EDTA)

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