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Anxiety Stricken

Home Access Test- What is a First Generation Test
      #7298 - 07/18/00 03:45 PM

I have taken the Home Access test which I have learned is a First Generation Test. I was negative at 35 days which made me happy. I know the window for the most modern ELISA tests is 25 days on Average. I also know that the Home Access uses a 1st generation test. But is this a newer type of first generation test that is sensative enought to pick up the antibodies at 35 days? Or, is it the same old Elisa tests used in the early to mid 90's with the 3 monnth period. Does anybody have any info on whether or not the First Generation Elisa is more sensative now than it was a few years ago? Thanks.

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Lets clear things out new
      #7299 - 07/18/00 04:53 PM

One thing is that antibodies test are so sensitive nowadays that can detect antibodies AS EARLY as 2 weeks or 3 weeks from infection and another things is that still the window period is for most people in the world 3 months and for organizations like the CDC 6 months. But no less than 3 months in any case. Tough I ve in Sweden they say 2 months, but the guideliness in Europe is to wait 3 months, not less. Altough a negative test at 35 can be said to be a good sign.

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Re: Lets clear things out new
      #7309 - 07/18/00 10:31 PM

I know there's been a lot of talk about different generations of tests. I participated in those discussions quite a bit with Not_Scared and I did some of my own research on it as well afterwards, just out of curiosity. This is what I've discovered.

You're right. The Home Access test is a 1st generation test. It uses the Vironostika (I don't quite remember the spelling) testing kit, which is based upon Viral Lysate technology. This, by definition, makes it a first generation test.

However, these tests have been vastly improved since their introduction in the 80s. So they are much more accurate right now than they were before.

As far as how accurate they are at 3 months, this is a questions that's not easily answered with my level of knowledge and research. But I can say that they are very close to the 2nd and 3rd generation ELISA tests in accuracy at that time. On this site, Not_Scared mentioned that he asked quite a few doctors about it, and they generally answered that it was somewhere in the high nineties in accuracy, and quite a few of them said it was 99% accurate. I'm not sure if doctors are the best people to ask about this though, because they aren't specialists in the tests like some microbioligists are, but I'm sure they know what they are talking about.

As far as the question of whether or not these tests are conclusive at 12 weeks, I really don't know. I live in Toronto, Ontario, Canada, and the ONLY test they use here is a 3rd generation test, so they say that it is conclusive at 12 weeks. When I asked the hotline here about an updated 1st generation test, they said that they didn't know how conclusive it would be (because they don't use it anymore). However, they too believe that it would be at least very close to conclusive. From what Not_Scared mentions, the New York State department of health takes a similar position to the Province of Ontario ministry of health. They test using a 2nd generation test, and say that it is conclusive after 12 weeks. But they are not 100% sure about a 1st generation test.

So, in summary, I think if you get a negative result on a 3 month test with a first generation ELISA, you're in amazing shape, and it would be very unlikely that you are infected. If you are tested with a 2nd or 3rd generation test, I personally think it would be conclusive. But of course, there are others who would argue with me and say you still have to get tested at 6 months. They could be right, but I personally don't think so. But I'm not an expert myself.

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Re: BDG, well said! new
      #7312 - 07/18/00 11:13 PM

BDG, that was so well-written (and not just because you quoted me!) that it was a joy to read it straight through!!
I talked with New York State Dept of Health's Medical Director again, and was told (again) that they cannot label as "CONCLUSIVE" a HOme Access test or Orasure at three months (it's a Vironostika 1st Generation ELISA, correctly spelled as you wrote it!). They will only guarantee a three month as "conclusive" with their synthetic peptide ELISA's (2d Gen) administered free at any state or city run clinic.
P.S. I hope things are going smooth with you!

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Re: BDG, well said! new
      #7344 - 07/19/00 05:26 PM

Thanks Not_Scared. Things are going smoothly with me (except for a couple of problems with my girlfriend - not HIV related though!). How about with you?

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Orasure disclosure... new
      #7356 - 07/19/00 08:30 PM

This was on the Orasure website...
Fair Balance Statement: The accuracy of the OraSure HIV-1 oral specimen test is lower than that of blood. It has been demonstrated to range from 97.7% in high risk subjects to 99.6% in low risk populations. Please refer to the Product Insert for details.

The product Insert is now under revision, so I couldn't check that...

Compare this to the website Q & A section:

How accurate is OraSure® HIV-1?

OraSure HIV-1 is a very accurate alternative to blood testing.. Doctors and clinics tested OraSure HIV-1 in thousands of people. The tests showed OraSure HIV-1 is more than 99% accurate. Even so, false results can occur with any test. Be sure to discuss your results with your health care provider. See Fair Balance Statement

(So in effect, are they misleading people?)

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