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How would LGV(clamydia) effect an elisa test
#44544 - 11/22/02 04:25 AM
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I've been diagnosed as having Lymphogranuloma venerum or LGV a tipe of clamydia. Apparently this can effect Elisa tests does any one know in which way False Poitive? or Negative.
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Where did you hear that it affects the test?
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Lymphogranuloma venereum
Provided by A.D.A.M.
I found this on the yahoo health I've been diagnosed to have this condition I first had the symptoms two years ago they passed and I thought nothing more of them then three months ago I came down with classic ars symptoms. Allergic reaction, hives, Macropapular rash, yeast infection on tongue, ulcers on the back of tongue, gingivitis and symptoms of mono. I did an elisa test at four weeks then six, nine and 12 all negative.. I would really appreciate an expert oppinion..
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Definition
LGV is a sexually-transmitted disease caused by the bacteria Chlamydia trachomatis that causes inflammation and drainage of the inguinal and lower abdominal lymph nodes, and destruction and scarring of surrounding tissue. These enlarged nodes are called buboes. This type of Chlamydia trachomatis infection is caused by a different type (serovar) of Chlamydia than that which causes other genital infections.
Alternative names
LGV; Lymphogranuloma inguinale; Lymphopathia venereum
Causes, incidence, and risk factors
Lymphogranuloma venereum (LGV) is caused by 3 subtypes of Chlamydia trachomatis and is separate from the types that cause eye disease, blindness and the more common genital chlamydia.
Lymphogranuloma venereum is more common in Central and South America than in North America. LGV has a variable incubation period ranging from a few days to a month.
It begins as a painless ulcer on the male genitalia or in the female genital tract. As the organism spreads, the inguinal lymph nodes swell, become tender and attached to the surrounding tissue (fixed), and finally rupture and drain through the skin.
The skin above the lymph node is often swollen (edematous) and red. These areas may appear to heal, but the patient will have relapses of lymph node swelling and drainage. The patient may also have systemic signs including fever, decreased appetite, and malaise.
In homosexual men and women who practice anal intercourse, the disease produces lymph node swelling around the rectum (perirectal). This is often accompanied by bloody rectal discharge, painful defecation (tenesmus), diarrhea and lower abdominal pain. Women may develop fistulas (connections) between the vagina and rectum.
There are a few thousands cases a year in the United States.
Risk factors are having multiple sexual partners.
Prevention
Abstinence is the only absolute answer to preventing sexually transmitted disease. Safer sex behaviors may reduce the risk. A monogamous sexual relationship with a person known to be free of any STD is adviseable. The use of condoms, both male and female types, markedly decrease the likelihood of contracting a sexually-transmitted disease but must be used properly. The condom should be in place from the beginning to end of sexual activity and should be used EVERY time the person engages in sexual activity with a non-monogamous partner or other suspect partner. Condoms are effective and inexpensive considering the consequences of contracting a sexually transmitted disease.
Symptoms
Small painless ulcer on genitalia
Swelling and redness of the skin over the inguinal lymph nodes
Swollen groin (inguinal) lymph nodes on one or both sides
Drainage from inguinal lymph nodes
Drainage of blood or pus from the rectum (blood in the stools)
Pain while having a bowel movement (tenesmus)
Signs and tests
The medical history and physical examination may show:
A history of sexual contact with a person having lymphogranuloma venereum
An ulcer on an affected person's genitals
A perianal fistula with drainage
Inguinal lymph node enlargement (inguinal lymphadenopathy)
Suppuration and drainage of inguinal lymph nodes
Tests:
CBC
Syphilis tests that can be truly or falsely positive
Biopsy of the node (chlamydia seen after staining)
Culture of a node aspirate for chlamydia (a needle is inserted into the lymph node and fluid is pulled out of the node)
Indirect immunofluorescence for chlamydia
Antibody test for LGV
This disease may also change the results of:
ANA
Immunoglobulins
Blood chemistry
Liver enzymes (ALT, AST)
Hematology - ESR
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Any doc's out there
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Where in any of that did it say that having that throws off an ELISA? I don't think it does.
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At the bottom of the text it says this
This disease may also change the results of:
ANA
Immunoglobulins
Blood chemistry
Liver enzymes (ALT, AST)
Hematology - ESR
Antinuclear antibody panel
Provided by A.D.A.M.
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An ANA TEST Definition
A test that measures the presence of antinuclear antibody in the blood
Why is the test done
This test is used when autoimmune disease is suspected (particularly systemic lupus erythematosus). This test can also be performed when a patient has unexplained symptoms such as arthritis, rashes, or chest pain.
So is The Elisa test An ANA test?
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Is the Elisa test an Antinuclear antibody panel
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It is known to create false positive results.
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That test would be different from an ELISA. Maybe that's why it doesn't say ELISA. It says that the ANA test is for auto-immune diseases such as Lupus.
If you had bothered to look up Lupus instead of just ASSUMING it meant the ELISA also you would have found that diseases such as Lupus are diseases where the disease causes the body's immune system to ATTACK THE BODY. Arthritis and Addison's disease also come under that category.
None of this has anything to do with HIV or the ELISA. Which is why you didn't see any mention of HIV or the antibody test for it, in the orginial article. To answer your orginal question, no what you have won't affect the ELISA test.
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