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False neg Thailand
#37611 - 07/29/02 09:16 AM
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Who ever wrote to Dr Ryan with this question please get in contact with me!
Q
Dear Ryan, Please let me begin by thanking you for this generous and invaluable service. I am a 26 yr old heterosexual male living in the UK. At the end of July 1999 I had an encounter with a woman in thatiland that involved brief exposure of my penis to her vaginal fluids. 6 weeks after returning I started to have diarrhoea, joint pains, oral candida, a droning headache with a sense of detatchment and occipital pain...the lot basically. Was ver worried about HIV at the time, so took HIV Elisa at 6wks, 2month,3months and 6months, antigen test at 2 months. All were negative. Also had psoriasis which begean then and prexisting dermatitis worsened. I still have persistent psoriasis, with bimonthly ulcers in throat and discharge from penis three years later. Do you think the diagnosis could have been missed due to non B subtype of HIV 1? Please help. Thankyou.
A
It is unlikely that your antibody tests were falsely negative. Antibody tests are fine tuned to detect virtually all subtypes of HIV-1. Nevertheless, since a small possibility of an antibody test not detecting a subtype of HIV-1 exists, it is recommended that you talk to your physician about your symptoms to determine if: a) they are indicative of HIV infection, and b) further screening for non-B subtypes is necessary.
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Didn't you already get additional screening? I thought you'd taken every test in the book already?
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Yes I had additional screening and they did look for the POL,GENE and GAG proteins but there was nothing to suggest that these tests were specifically for non b subtypes, even the bDNA I took is not conclusive. Whoever this guy is I would like to correspond with him, he also lives in the UK and like me is going to have a bitch of a task getting any other test besides the standard ELISA which one of the healthcare workers said was geared toward b subtypes, not much good in mine or his case.
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Well if you insist on pursuing this you will, just remember that a) you've already had a lot more tests then this guy and b) don't rise above the fact that the first part of the answer was....'It is unlikely that your antibody tests were falsely negative. Antibody tests are fine tuned to detect virtually all subtypes of HIV-1.'
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Oh no! Thought the Antibody test was ssoooo infallible? YEAH RIGHT!!!
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