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HIV Transmission and Education >> Am I Infected?

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      #34197 - 05/12/02 01:01 AM

Has any reported strains been reported from people testing negative and really are positive? any links to look at on the subject? What are likely senerio's to go undetected by elisa screening other that window period?
Thank you

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Reged: 10/26/00
Posts: 2028
Re: elisa's new
      #34201 - 05/12/02 03:02 AM

Yes Chris,

There have been rare cases. Go look on the experts Q&A board. You can do a search on each board. Just type in say... 'Type N'. Then you can read all about a strain the has like 3 or 4 reported cases out of millions.

Sleep well!


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Re: elisa's new
      #34207 - 05/12/02 12:22 PM

The window period: The time delay from infection to positive EIA averages 10 to 14 days with newer test reagents (Clin Infect Dis 1997;25:101; Am J Med 2000;109:568). Some do not seroconvert for 3 to 4 weeks, but virtually all patients seroconvert within 6 months (Am J Med 2000;109:568). Prophylaxis with antiretroviral agents and acute hepatitis C infection may prolong the time from transmission to seroconversion.
* Seroreversion: Some patients serorevert in late-stage disease (JAMA 1993;269:2786; Ann Intern Med 1988;108:785). Seroreversion may also occur in patients who achieve prolonged immune reconstitution due to highly active antiretroviral therapy (HAART) (N Engl J Med 1999;340:1683).
* "Atypical host response" accounts for rare cases and is largely unexplained (AIDS 1995;9:95; MMWR 1996;45:181; Clin Infect Dis 1997;25:98).
* Agammaglobulinemia
* Type N or O strains or HIV-2: EIA screening tests may fail to detect the O subtype (Lancet 1994;343:1393; Lancet 1994;344:1333; MMWR 1996;45:561). This strain is rare; only one patient with strain O HIV infection was detected in the United States through July 1996 (MMWR 1996;45:561; Emerg Infect Dis 1996;2:209). The N group is another variant that causes false-negative EIA screening tests, but may be positive by WB (Nat Med 1998;4:1032). There have been no recognized infections with the N strain in the United States through March 2000 (J Infect Dis 2000;181:470). Standard EIA screening tests are falsely negative in 20% to 30% of patients infected with HIV-2. Detection may require tests specifically for HIV-2. Risks for HIV-2 are summarized above.
* Technical or clerical error


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