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John Bartlett
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Seroconversion
#32030 - 04/14/02 06:54 PM
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Seroconversion
By John G. Bartlett, M.D. (24-Jan-2002)
Dr.
In response to a question posed on April 21, 2001 you quoted "The Medical Management of HIV Infection" (Bartlett & Gallant) as saying:
The window period: The time delay from infection to positive serology (EIA and WB) averages 21 days with newer test reagents (CID 1997;25:101).
A review of the current text posted indicates the following:
The window period: The time delay from infection to positive EIA averages 10 to 14 days with newer test reagents (Clin Infect Dis 1997;25:101; Am J Med 2000;109:568).
Can you help clear up the time frame from infection to positive serology ?
The sequence of events with testing is the following:
Day 0: HIV transmitted
Days 8-14: HIV RNA becomes detectable (This is the "eclipse time" and requires sufficient replication for detection. Some cases have a substantial delay.)
Days 16-17: HIV p24 antigen becomes detectable.
Day 23: EIA screening becomes positive. The time of a positive WB depends on the kit.
All data above are averages. Nearly all standard serologic tests are positive by 6 weeks.
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This Dr. as been studying HIV/AIDS for along time.
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