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Seroconversion
      #193310 - 05/26/06 03:51 PM


Seroconversion
By John G. Bartlett, M.D. (24-Jan-2002)


Dr.

In response to a question posed on April 21, 2001 you quoted "The Medical Management of HIV Infection" (Bartlett & Gallant) as saying:

The window period: The time delay from infection to positive serology (EIA and WB) averages 21 days with newer test reagents (CID 1997;25:101).

A review of the current text posted indicates the following:

The window period: The time delay from infection to positive EIA averages 10 to 14 days with newer test reagents (Clin Infect Dis 1997;25:101; Am J Med 2000;109:568).

Can you help clear up the time frame from infection to positive serology ?

Answer:

The sequence of events with testing is the following:

Day 0: HIV transmitted
Days 8-14: HIV RNA becomes detectable (This is the "eclipse time" and requires sufficient replication for detection. Some cases have a substantial delay.)
Days 16-17: HIV p24 antigen becomes detectable.
Day 23: EIA screening becomes positive. The time of a positive WB depends on the kit.

All data above are averages. Nearly all standard serologic tests are positive by 6 weeks.

http://qa.hopkins-aids.org/forum/view_question.html?section_id=62&category_id=125&id=46871


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dj1979
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Reged: 03/02/06
Posts: 276
Loc: rural upstate NY
Re: Seroconversion new
      #193466 - 05/28/06 11:17 AM

My timeline goes like this:

Jan. 10th - app. date of exposure
Jan. 31st - became acutely ill with ARS
Feb. 14th - initial testing - ELISA positive, Western Blot indeterminate
Feb. 28th - repeat testing - ELISA positive, Western Blot positive
March 14th - I got the results of the Feb. 28th testing
March 21st - Initial labs - viral load 43,600, CD4 of 569.



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