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Seroconversion
#187186 - 04/20/06 12:42 PM
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I've searched high and low, near and far all over the internet and am yet to find an article on late seroconversion. Whether its after 3,4,5,6.....12 months. Has anyone read anything on this subject in the internet?
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MiamiLat
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Guardian
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Reged: 12/30/05
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You haven't searched that hard because it's everywhere, but here goes...
Most people will have detectable antibodies in their blood by 6 weeks, with the average time being about 25 days. A conclusive test is considered at 3 mos (12/ 13 weeks) since 99+% of those infected will test pos by then.
Late seroconversion is a term used for the <1% who test positive after 3 mos. Please note this is a very rare occurance and occurs with those with severely compromised immune systems such as individuals under chemotherapy, those taking meds after organ transplants, and long term IV drug users. A test at 6 mos would catch these late seroconverters. No ones tests positive after 6 mos unless they have exposed themselves again.
Best Wishes
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"Education, prevention, awareness, research, and support"
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not correct miamiLat!
There are several publications , the last one Feb 7 ,2006 .you can find it in the main page of thebody.com , latest news. This is a person who seroconverted after 12 months. There are 3 more cases documented form Health care professionals who after exposure took PEP, their converted at 8 , 9 and 13 months. One of this was a nurse from Chile, case is also reported.
I do agree ,however, that these are rare cases, but they are documented, specially scaring is the case described in thebody article, as reasons for this late seroconversion are not clear at all
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sadface
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Legend
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Okay, now I am really a wreck!!
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OK Anon I did find the seroconversions of the 3 health care proffesionalas but no the one of the person seroconverting at 12 months. Can you provide the link to the documentation? I'd like to know what kind of exposure this person had, testing data, and was it protected or non-protected sex.
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I read the article dated Feb. 7, 2006 found here on TheBody. The article describes this as a "single unusual case". It is unclear whether this person had a compromised immune system to begin with.
As for the 3 other cases you state, if they are accurate, it is possible PEP played some role in delaying antibody production. Nevertheless, 3 or 4 out of the over 40 million infected still qualifies this as a rare occurance.
I still stand by my earlier post...
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MiamiLat
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This was me (I don't know how it got entered as anonymous):
I read the article dated Feb. 7, 2006 found here on TheBody. The article describes this as a "single unusual case". It is unclear whether this person had a compromised immune system to begin with.
As for the 3 other cases you state, if they are accurate, it is possible PEP played some role in delaying antibody production. Nevertheless, 3 or 4 out of the over 40 million infected still qualifies this as a rare occurance.
I still stand by my earlier post...
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"Education, prevention, awareness, research, and support"
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shadow1
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Jut think of all that information on the webpage’s I posted last week, as I expected it all went to waste because no one wants to read. I guess I figured that, but in all of those sites, I posted last week there were hundreds of articles on seroconversion and the timeframes and what causes delays and the average length it can be delayed. However, I guess it was all for nothing as most of my responses.
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MiamiLat
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GmanBill,
Your responses are always appreciated. I remember your post with all the links. It's just easier to summarize the information and just write it out since some folks don't have the time to follow each link. However, the same questions will always re-appear no matter what...
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"Education, prevention, awareness, research, and support"
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JonCage
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It is possible to seroconvert after 3 months although extremely rare. The 3 month window was established to catch even the most outer liers that seroconvert.
You cannot assume that a case mentioning seroconversion after 6 months or 12 months is factual. Patient report is deem highly unreliable as many people do not recall the exact date that they were exposed or they somehow forget about other exposures within the window period. You can only rely on studies where the reports have been reviewed by other reliable sources and all have done there own independant study and reach the same conclusion.
Each individuals body is unique and responds to things differently. The report does not mention the patients clinical history. We do not know what other ailments the patient suffered from or any other conditions. To generalize and accept the idea that delayed seroconversion occurs in healthy individuals is not realistic. If it was such a concern, the CDC would still be recommending a one year window as it did several years ago.
Again, you cannot believe everything you read, even if it's reported on thebody.com. If you believe such things, I recall a british male who cured himself of HIV and is now suing the laboratory that completed his test. If you believe in the odds of seroconversion after 6 months, you may also tend to believe that humans can rid themselves of HIV.
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Red like love, as a symbol of passion and tolerance towards those affected
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I think you can seroconvert between 6-12 months. the only
reason the cdc documented the health care workers cases
is because they believed them. why would they believe
anybody else?
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I guess the possibility that aliens are out there is also plausible!!!! Seroconverting after 6 months is something out of this world with today's tests. The CDC is the most conservative organization with its guidelines. In Western Europe the guidelines are 3 months and that's it. I highly doubt that someone can seroconvert after such time or we would have many cases not just "some."
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