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Blood Supply
      #183974 - 04/03/06 06:38 AM

Just a quick query on what is done to keep the blood supply safe?

I know that tests are run on all blood that is donated but how do they detect HIV in the blood of someone that is in the window period?

E.g. If someone was to donate 3 or 4 weeks after they were infected and had not seroconverted how is their blood stopped from being donated to someone?

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Re: Blood Supply new
      #183978 - 04/03/06 09:38 AM

The Red Cross uses NAT testing. It's more sensitive, but very similar to the Gen IV ELISA test.

There is an antigen that is present before antibodies develop. These tests are able to pick up the P24 antigen within a few weeks.

Mass uses the 4th gen test which is why they say 6 weeks is conclusive. You either will test postive by antigen within a couple a weeks, or by antibodies by 6 weeks.

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Re: Blood Supply new
      #183982 - 04/03/06 11:36 AM

Ah cheers - that makes sense.
So basically (except in the early early stages of infection) if antibodies are not yet detectable then the p24 antigen will be? I.e. If a person does not have enough antibodies to test positive on a Gen IV ELISA they will most likely test positive on a p24 antigen test (if infection occured at least 2 weeks or so prior to the tests). Is that right?

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Re: Blood Supply new
      #183988 - 04/03/06 12:52 PM


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Reged: 11/19/05
Posts: 1148
Loc: Adelaide, Australia
Re: Blood Supply new
      #184203 - 04/04/06 02:25 PM


regards from india

If blood pathogens are indeed present in the donor's blood, the blood is NOT fit for blood supply and the blood bank would ensure it not supplied, it is well eqiupped with tests to do that, however sporadic incidences of infected blood being supplied may happen.


Take Care

God Bless you

Stay Well

Love Ravi

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