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waiting time ?? different view ?
#171409 - 01/25/06 08:37 AM
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Dear All,
I am written from Spain. I had a negative Elisa test at 39 days after exposure . I also have a negative PCR RNA test at 42 days.
My doctor is telling me 100% I am OK, but looking into this forum and the questions to the doctors , I started to be scared. It is true that one of the doctors (Dr.Holodniy) in a replay to a Aug 1999 question is saying that he has not seen any PCR RNA test negative after 4 weeks tourning positive after... but, may of you are saying in the forum that PRC test is useless. SOme other people is saying that is not approved by FDA mainly because cost and high risk for false positives...BUT, if you have negative is OK ??
Please to who may can help, any scientific evidence of PCR as a system to reduce the window period ?? Should I trust the result and my local doctor ?? thanks for any comment.
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The problem with PCR tests is that they have a relatively high rate of false positives. The technology involved is very sensitive and so any minor contamination can cause this. That is why they are not recommended for diagnosis.
The facts are these:
1. Most people who are infected with HIV will have a detectible level of virus by 48-72 hours. It is extremely rare (but not completely impossible) for people to test not have a detectible level of virus after 28 days. So your PCR test is a very good indication.
2. The reason why a very few people do not have a detectible level of virus after 28 days is that they have produced antibodies and suppressed virus production. So no virus and no antibodies being detected is a wonderful combination.
Therefore your doctor is correct. Barring the extraordinarily low possibility of lab error or the possibility that you are some sort of medical freak, you are HIV negative. The official advice would be to take an antibody test at 13 weeks to be sure. However, if you want to bet me one million dollars on this, I will bet you that you are negative....and I am deadly serious. Do you have one millions dollars?
God bless!
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Thanks so much!. Unfortunatelly, I do not have the 1 m $ to bet, ... again, I really hope you and my doctor are correct.
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trust the doctor
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OK - forget the US$ 1 million, I'll take a "Cafe con leche" next time I am in Madrid!
Seriously though, your Dr. is right. You are fine.
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I had a neg . oraquick and a pcr rna undetectable at 400 at 36 days,I red the same post felt reasured than concerned when I saw the recent one on the same forum "my doctors are shocked!!"...Has anybody heard of a seroconversion with undetectable viral load?.
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no cases as far as I know. HOwever, there is always the possibility of a mistake in the first analysis...., but that should be minor as the ELisa is also negative...and two mistakes is a major thing. My opinion: this could be a way to reduce the 12 weeks, it is quite expensive, needs to be done in private hospitals to get results in 2-3 days ( otherwise your PCR results will come out at 3-4 weeks later , so close to the 9-10 weeks of the incident...).. and this could be the one of the resaons for not being used. also , remember that you may have a falsa positive with PCR ( 2% -9%) and then your anxiety will significantly increase, so , it is risky and expensive , but if you have a Elisa negative at above 5 weeks, a PCR RNA not detactable (<400) at the same time, and you are not a medical freak... THEN YOU MUST CONCLUDE YOU ARE NOT INFECTED.
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