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accept your results
#13973 - 12/18/00 10:29 AM
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look up serologic testing in webmd. again with the third gen elisa the window has shortened.
Accuracy of Screening Tests
The initial screening test to detect antibodies to HIV is the enzyme immunoassay (EIA). Commercially available EIAs use antigens from whole disrupted virus (first generation), recombinant viral proteins (second generation), or chemically synthesized peptides (third generation).22 EIA results are considered "reactive" only when a positive result has been confirmed in a second test of the original sample. In subjects with clinical AIDS, the sensitivity of EIA is close to 100%, but newly infected individuals may not develop detectable antibodies for periods of weeks to months after infection.23 The median interval between infection and seropositivity has been estimated at 3 months with earlier EIAs, with 95% seroconverting within 6 months.24 Estimates based on more sensitive third-generation EIAs, which may be positive within 1 week of peak antigen levels, suggest that the "window" period with current tests is substantially shorter (3-4 weeks).25,25a Specificity of EIA is above 99.5% with most tests. Third-generation EIAs had specificities of 99.7-99.9% when tested against uninfected controls.25-27 False-positive results can be caused by nonspecific reactions in persons with immunologic disturbances (e.g., systemic lupus erythematosus or rheumatoid arthritis), multiple transfusions, or recent influenza or rabies vaccination.28,29 Food and Drug Administration (FDA) approval has been granted to rapid tests (<15 minutes) using colorimetric assays,30 and to an EIA-based test using oral fluid samples collected with a cotton pad.31,32 Although these tests are sensitive and specific (>99%), neither method is recommended for the definitive diagnosis of HIV infection.33
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now uses third generation elisa test all over the world or are there some people still performing first generations test. Wouldnt it be like trying to buy a Pentium first generation chip nowadays (almost impossible) for labs to buy a first generation test when almost all companies would have discontinued those test and make only third generation tests? Wouldnt you know?
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believe it or not there are still places that use the older tests (call home access). go to a reputable lab, ask them what test they use before you take one and if its a third gen. then thats it.
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