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group N difficult to be identified!
#112334 - 10/05/04 09:26 PM
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1: AIDS Res Hum Retroviruses. 2004 Aug;20(8):902-8. Related Articles, Links
Identification and genomic sequence of an HIV type 1 group N isolate from Cameroon.
Bodelle P, Vallari A, Coffey R, McArthur CP, Beyeme M, Devare SG, Schochetman G, Brennan CA.
Abbott Laboratories, Abbott Park, Illinois 60048, USA.
HIV-infected plasma specimens, collected in Cameroon between 1999 and 2002, were screened for HIV-1 group N and SIVcpz infections using a serological screening algorithm based on immunoassays with antigens derived from HIV-1 group M, N, and O, and SIVcpz strains. Specimens with reactivity to group N and SIVcpz antigens were characterized by RT-PCR and sequence analysis to identify the infecting virus. Although several specimens were serotyped as potential group N or SIVcpz infections, only one group N infection was confirmed. The specimen, 02CM-DJO0131, was collected in 2002 from a hospital patient at the D'Joungolo Hospital, Yaoundé. The virus genome was amplified as seven overlapping fragments comprising 8938 nucleotides. Phylogenetic analysis shows that 02CM-DJO0131 branches with group N sequences. With this study, three near full-length sequences are now available for group N. While we confirm the presence of group N in the Cameroonian population, group N infections continue to be rare and difficult to identify.
PMID: 15320995 [PubMed - in process]
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How do we know it's rare if we can not identify it (or other variants) I guess one must wait 7 to 10 years for a AIDs defining illness with low CD4 count
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I read like a textbook case study in HIV, yet all my tests test negative. I believe I am carrying this. Like you, I guess i'll keep my fingers crossed for the next few years, as my tcells continue to fall.....
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me too!
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