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HIV Health and Treatment Issues >> Treatment & Side Effects

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Reged: 01/02/12
Posts: 25
Atripla vs. Complera vs. Truvada: How to decide?!?
      #261408 - 02/25/12 01:28 AM

I've combed over these three drugs and it all runs in circles. I lean toward one then the other. Can any one offer their experience as a reference?

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Reged: 10/25/10
Posts: 1131
Loc: GA, USA
Re: Atripla vs. Complera vs. Truvada: How to decide?!? new
      #261418 - 02/25/12 10:44 PM

Truvada is a component in both Complera and Atripla. It is a combination of two medications (emtriva and viread) which are both NRTIs (nucleoside reverse transcriptase inhibitor). It is highly suggested and considered good practice to use a NNRTI (non–nucleoside reverse transcriptase inhibitor) along with a two NRTIs. This helps the body fight off the virus by preventing the reproduction and initial infection of the cells for the reproduction process. Atripla uses sustiva as its NNRTI and complera uses edurant as its. Sustiva has been shown to cause an increase in mental disorder severity in people who have or have had a history of mental health problems. Sustiva also is best absorbed into the body on an empty stomach (so not to flood the system with all the med at once). Edurant can also cause mental health issues but with less likelihood. Edurant can be taken with food and must be taken with food to ensure proper exposure to the drug. (Usually with a large meal consisting of more than 500 calories, a cheeseburger from McDonalds covers that.)

I've been on both. First Atripla, I stopped the use of that due to sleep issues. I was only sleeping on avg 3-4 hours a night and most of the time even that was interrupted. I've heard other people say that they haven't slept better. So 6 on one hand half a dozen on the other. I switched to Complera and now I sleep (when people let me lol) and have no issues. Heard others complain about running to the bathroom and not being able to sleep. At any rate truvada should not be prescribed alone is my point and asking which med is better is not really going to get you anywhere because each have their ups and downs and no one can say how you will do on either.

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Reged: 02/02/11
Posts: 464
Loc: Thailand
Re: Atripla vs. Complera vs. Truvada: How to decide?!? new
      #261428 - 02/26/12 04:55 AM

Yep, Truvada must be used in conjunction with another med from another family. I have heard horror stories here that a doc who didn't know what they were doing prescribed it by itself - it must always be paired with another med, such as Sustiva/Stocrin.

I'm on Truvada + Stocrin (=Atripla) and have done well. My girlfriend is on it as well and is doing great. One thing I am finding out is that you also need to get plenty of rest and avoid stress to help your meds do their job.

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Reged: 05/20/10
Posts: 39
Re: Atripla vs. Complera vs. Truvada: How to decide?!? new
      #261728 - 03/09/12 08:31 PM

I've been on Atripla since 9/10. Within the first three months, my VL went undetectable. I don't have the vivid dreams some have experienced and really didn't have any issues at all with the meds. I suppose I lucked out.

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Reged: 02/13/09
Posts: 40
Re: Atripla vs. Complera vs. Truvada: How to decide?!? new
      #262234 - 04/03/12 11:12 PM

my specialist advises that Complara isn't quite as strong, thus not recommended for people with a high baseline viral load, like 100,000 or more. So, if you are starting meds early, it might be good, but if starting late in the game, might not be good.

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Reged: 03/19/12
Posts: 12
Loc: MN, USA
Re: Atripla vs. Complera vs. Truvada: How to decide?!? new
      #262442 - 04/12/12 04:32 AM

I am on Truvada, Norvir, and Prezista due to a long history of heart burn and a short history of stomach ulcers. Some meds require the stomach acid for absorption so there are other factors that may impact your med options. In my case, I seem to be doing well on this regimen though I seem to have to calibrate my meal with my meds a little.

Just a little food for thought.
What time will you take it? What other health issues do you have? Any allergy or reactions to meds? What does the med need to be processed correctly (with food, without food, stomach acid, etc)? Any predisposition to conditions like mental health issues based on personal or family history?

In my case, my doctor did most of it and luckily I had been in the hospital prior and really "rooted out" the majority of the issues I could have that would impact the medications.

Also remember, Laughter is always the best medicine and doesn't have any possible negative medical interactions.

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Reged: 05/28/12
Posts: 7
Loc: London UK
Re: Atripla vs. Complera vs. Truvada: How to decide?!? new
      #263460 - 06/02/12 11:37 PM

I went through the same thing with Atripla / Complera or Eviplera as its known in the uk.

Ultimately my main concern was my history of depression and so Complera won. That was 2 days ago now and so far so good, I was even out drinking last night and no complications there.

My advice to anyone would be talk things over thoroughly with the doctor, the pharmacist and any clinical nurse specialist too. They all have different insights and can offer their experiences

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