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detection of hiv infection in infants
Jul 6, 2001

how we will detect intrapartum,interpartum & post partum hiv infection in infants?how much it is important?

Response from Dr. Luzuriaga

Babies can acquire HIV during gestation (in utero), during delivery (intrapartum), or after birth (post-partum; through breast feeding). Timing of infection can usually be inferred by screening test (DNA PCR) results. A positive DNA PCR at birth suggests in utero infection. A negative DNA PCR at birth with a positive result between 1 week and 8 weeks suggests intrapartum infection; in breastfed populations, this could also be due to early transmission through breast feeding. Negative results at birth with positive results after 8 or more weeks suggest breast milk transmission. Some studies have suggested more rapid progression in infants infected in utero. However, outcomes do not appear to differ appreciably when infants are identified early and have access to early potent antiretroviral regimens.


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