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infant zidovudine: recommendations for dose escalation with weight gain?
Apr 12, 2004

I know standard dosage for zidovudine for an infant born to an HIV positive mother is "2 mg/kg body weight q6h" as part of the MTCT prevention. In 6 weeks time however, an infant easily weighs a kilo, to 1.5 kg more which is up to 50% of its birth weight. How often do you have the infants checked for weight gain in order to change the dosage?

Response from Dr. Luzuriaga

In our clinic, we usually see babies at 1 and 4 weeks to see how things are going, check their weights, and to draw bloods to check for infection. If weight is increased by more than 10% of the baby's previous weight, we adjust the dose. If weight is down at 1 week, we usually do not decrease the dose, since the baby is expected to grow -- any babies that lose weight over the first week are usually seen again at 2 weeks to re-check weights. Dose adjustment is relatively uncommon during the first week but fairly common at week 4 .

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