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Nevirapine in babies
Jun 11, 2003

Hi,

We are implementing a PMTCT programme since 2001. We have introduced Nevirapine in June 2002 and very soon we will be expanding the programme to other sites. Can you help me to answer the following question: Can we give Nevirapine to the newborn from an HIV positive mother during the first 6-8 hours postpartum or in other words what is the appropriate time to give it in a setting where it might be difficult to follow up with the baby.

Thanks for your help.

Response from Dr. Luzuriaga

You don't mention whether or not you are giving nevirapine to the mother. If you give nevirapine to the mother at delivery, the baby should have good levels of nevirapine through at least 48 hours; you could then give another dose to the baby to provide levels through the first week. If mom does not receive nevirapine, then the baby should receive nevirapine as soon as possible after birth (best within 6-8 hours). Single doses of nevirapine have been safe and very well tolerated by babies, so an inability to follow-up should not precllude administration of nevirapine to infants at risk.


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