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Longterm impact of HIV meds given during pregnancy on infant
Mar 30, 2003

I am working with a young HIV+ mom who took Combivir and Viramune during her pregnancy. Her Child received AZT at birth and was treatment until 2month and has consistantly tested negative. However, The child is experiencing a number of developmental delays. He is approximately 6 months behind in his development. Mom is concerned that this was in some way associated with her HIV treatment during pregnancy. Question: Is there any research, feedback or longterm impact of HIV meds during pregnancy, delivery and early life on the development of the infant??

Response from Dr. Luzuriaga

The evaluation of possible long-term effects of infants' exposure to antiretroviral therapy is an area of active research and follow-up. While one group in France has reported an apparent associateion between antiviral therapy and neurologic problems due to mitochondrial dysfunction, other studies have not confirmed that link. There are many possible reasons for your friend's child's developmental delay. She should mention her concerns to her pediatrician and ask for a thorough evaluation with testing to determine the possible cause. She should also ask if he/she can recommend any services such as early intervention, speech or physical therapy, etc. that might help her child.

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