Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered.
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Pregnancy & HIV medication
Dec 11, 2000
My question is what know side effects do the following medications have on the fetus during pregnancy:
crixivan 400 mg
zerit 40 mg } these are the meds i am on since 1997
epivir 150 mg
sustiva 200 mg
combivir 150 mg } these are the meds my husband in on since 1999. neither of have children and really want to have a family any information will be helpful.
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Response from Dr. Jackson
None of the drugs you listed have actually been shown to cause birth defects to the human fetus, but none have been studied well in pregnant women except for AZT. Sustiva, however, has been shown to cause serious birth defects in fetal monkeys and consequently has rarely been used in human pregnancy. AZT has been shown to cause cancer in fetal rodents exposed to AZT, but so far this has not been found in humans.
Crixivan does not appear cause birth defects in small numbers of pregnant women studied to date, but it can cause hyperglycemia in pregnant women.
BJ
Brooks Jackson, M.D.
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