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Lipodystrophy and WastingLipodystrophy and Wasting
           
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wasting vs. lipodystrophy
Apr 14, 1999

How is the wasting syndrome related to lipodystrophy? Is the bottom line, in both cases, the same? Can they be treated with the same drugs (HGH, testosterone, oxandrin)?

Response from Dr. Fisher

Lipodystrophy relates to three components: hyperlipidemia (high levels of cholesterol and triglycerides in the blood), insulin resistance (high blood sugars), fat redistribution (either fat accumulation or fat wasting in specific body areas). This is a new syndrome (by the way, not yet precisely defined) that is different from AIDS-wasting or weight loss. LD is primarily related to protease inhibitors (but not exclusively) whereas wasting is primarily a complication of HIV infection itself. We still know very little about LD, especially the role of interventions such as HGH, testosterone, oxandrolone, though all of these agents have a clear role in treating and preventing wasting.

Alvan Fisher, M.D.


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