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Lipodystrophy and WastingLipodystrophy and Wasting
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metformin for lipodystrophy
May 3, 1999

I recently heard that there may be a possible new treatment for lipodystrophy. Do you know anything about using something called "Metformin"?

Response from Dr. Fisher

yes, metformin is actually a treatment for diabetes. It works by increasing cellular sensitivity to insulin. This has nothing directly to do with lipodystrophy, but a related component to lipodystrophy is insulin resistance (IR). IR is exactly what metformin is useful for. So in my patients with HIV-associated diabetes I regularly prescrive metformin. However since lipodystrophy itself is probably not caused by IR, I doubt metformin will help lipodystrophy (i.e. the fat redistribution). Alvan Fisher, M.D.

Fat redistribution
veins that show

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