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Lipodystrophy and WastingLipodystrophy and Wasting
          
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lipodystrophy treatment
Apr 5, 2001

Do you have any experience or knowledge regarding the use of Avandia in patients who have normal blood sugars to treat central fat accumulation or depletion of facial fat?

Response from Dr. Fisher

In a word, nope. This type of drug will combat insulin resistance but has not really been studied in HIV-associated lipodystrophy. One study with a similar drug, metformin, did show good results in terms of insulin resistance, blood pressure, weight. But the study was unlikely to show any effects on LD. I do not think there is a consensus that insulin resistance is the cause of LD, though it certainly is involved in the development of LD. In the absence of insulin resistance the drug could potentially be harmful by the way. AF


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