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Lipodystrophy and WastingLipodystrophy and Wasting
           
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Lipodystrophy from HIV meds
Feb 10, 2001

Dear doctors, Which HIV meds provedly causes lipodystrophy (weight loss, facial wasting, increasing of cholesterol and tryglicerides,...)? What kind of lipodystrophy which one causes? Thanks a lot. FT.

Response from Dr. Fisher

All antiretrovirals have been associated with LD. None are innocent. However aspects of LD can occur in people who have never taken HIV meds!

In general I can say the following:

nucleosides: fat wasting more than fat accumulation

PI's: fat accumulation more than fat wasting

Non-nukes: least effect

Cholesterol and Triglyceride elevations mostly from PI's, especially Norvir and Kaletra, less so with Agenerase

Diabetes mostly associated with PI's

Women experience different patterns than men

Age and duration of HIV infection are also factors

Hope this helps

AF


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