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Lipodystrophy and WastingLipodystrophy and Wasting
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Mar 3, 2002

Im a 43 year old man, HIV+ for 12 years, taking combos since 1998 (last 6 months: AZT, 3TC and Abacavir) Lab results: CD4=800,VL=300 and free testostenone=22,5. I'm suffering from lipodystrophy (I've lost fat - in face, arms and legs - and muscle mass), even after switching combo. Im considering to start a treatment: Megestrol 400mg/day and a steroid (Nandrolone 100mg/week or Oxandrolone 20mg/day) plus an excercise program. Questions: Which side effects could Megestrol causes me after some time? In general steroids increase muscle mass, but could they decrease fat deposits? How long could I safely take these steroids? Are those dosages appropriate and effective? Would you suggest taking any thing else? Thank you dear doctor. Your answers will be appreciated a lot. FF.

Response from Dr. Dieterich

Megace is a female hormone which will decrease your testosterone level as will the nandrolone or oxandrolone. You can look up the list of side effects elsewhere, but there are many of them. The megace may add fat to your frame and may or may not help to replace your cheeks. The other steroids will help build muscle but you may end up having to add testosterone after a while because of the feminizing effect of megestrol. Good luck! DTD

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