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Lipodystrophy and WastingLipodystrophy and Wasting
          
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NEJM article
Feb 27, 2002

Hello. There was a paper in the New England Journal yesterday about patients with diabetes and lipodystrophy who were successfully treated with leptin...to the point they needed no diabetic meds or insulin. Although the sample size is small, the results seemed quite dramatic. A couple of questions: 1. I didn't see any mention in my cursory review of the paper that there was any effect on reversal of lipoatrophy. There was weight loss, primarily attributed to reduction in liver size. Would one expect normalization of subcutaneous fat eventually, or does no one have an idea about that yet? 2. Will this be tested in HIV patients, and is it commercially available? Thanks very much.

Response from Dr. Dieterich

Interesting article! So far it does not look like there is much recovery of subcutaneous fat. However it is still early in the course. In HIV patients all the other parameters seem to recover but subcutaneous fat rarely does. DTD


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