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New Protease Inhibitor
Aug 18, 2000

Hello doc. Are you aware of a new protease inhibitor from Bristol Myers called BMS-232632? It's supposedly more potent than any known protease inhibitor, but I don't have any information on the current phase it's in...

Response from Dr. Pavia

BMS-232632 is a new protease inhibitor that is being developed by Bristol Myers Squibb. Luckily, it is about due to get a real name. The studies presented so far have demonstrated that it has a long half life and probably can be used as a once a day drug. In addition, it is active against many strains of HIV with resistance to one protease inhibitor. There are fewer data on highly multi-resistant virus. The drug is entering phase 2-3 trials around the country. You can keep an eye out for trials that are enrolling by calling 1-800-trials-A, or looking for trial information on this site, HIVinsite (www.hivinsite.ucsf.edu), and the AIDS clinical trial information service (http://www.actis.org/)

Hope this helps



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