|IL2 Low Dose
Aug 19, 2001
Dear Doc, I want to discuss with my Doc,the possibility of doing some low dose IL2. How much is low dose? How often and how long? Have you ever heard of depression being a side effect of low dose or is that only at high dose? Keep up your good work, your doing a great job. Toronto
| Response from Dr. Cohen
IL-2 is one of those meds with lots of info, and lots of controversy.
One controversy is whether it does something we need to do with medication other than antivirals alone - and that explains why there are very large international studies going on randomizing people to treatment either with or without IL2. And one of these years we will have an answer. Until then we have controversy. And it is still unclear what IL2 does for us - other than changing the CD4 counts we measure.
Another uncertainty is the dose. There are side effects at most doses - although far more toxicity as we increase the dose. There is no clear definition of what is a "low dose" as it depends on what you are trying to accomplish. If the use if the usual one, meaning you are going for a boost in the CD4 counts, the most proven way to do this is a dose of about 3 to 5 million units of IL-2 given once or twice a day for five days per week, and this five day cycle is done about every 2 months or so. This approach has resulted in increasing the CD4 counts, and has done so without increasing the viral load. But yes depression and other side effects can be seen even at this dose. Not in everyone of course, but can occur in some. Now there are even lower doses that have been studied and these are even more controversial in that there are fewer data to support the use of lower doses, although research continues on this.
Hope that helps. Thanks for the compliment, by the way....
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Monolaurin And Hiv
- Hiv Aids Terminal Illness
- Currently It Is Estimated That The Longest Time Between Hiv Infection And Onset Of Symptoms Is About How Many Years
- If I Have Sex With A Man Who Is Hiv Negative Then Can I Get Hiv?
- Atripla And Food
- How Long Does It Take For Thrush To Leave The Mouth After Treatment Starts?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.