|soft gel form of saq
May 6, 1997
Dr. Gallant, do you know when the soft gel formulation of saquinavir is going to be available, and exactly what difference/significance, if any, will this new form make? Will it decrease side effects, improve absorption, or what? Thanks! Carl
| Response from Dr. Gallant
Carl, I'm sure that the new formulation will be available sometime this year, but I can't be more specific. The point of the soft-gel capsule is to improve absorption. The bioavailability of the current formulation is about 4%, meaning that 9% ends up in the toilet. The new formulation will do better, though I'm told that bioavailability will still be only about 12%, and you'll still have to take a hefty number of pills.
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