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Protease Inhibitor Protocol for Children
Jun 10, 1997

Is there a protocol for protease inhibitors for children? One of our clients is a six year old little girl. She's on AZT. Her CD4 count is below 500. Should she be on protease inhibitors? Executive Director of an AIDS organization

Response from Dr. Cohen

I'm not sure what you mean by "protocol." There are a number of clinical trials for children that involve protease inhibitors. Protease inhibitors are also licensed for use in children. Ritonavir (Norvir) is available in a liquid formulation, and nelfinavir (Viracept) is available in a "sprinkle" form that you can mix with food. The same considerations apply to children as to adults; that is, protease inhibitors should always be used in combination with other antiretroviral agents that the child is not resistant to.

I can't tell you whether or not this particular child should be on a protease inhibitor. It would be important to know what her viral load is before making that decision.

Diarrhea with nefinavir
nelfinavir+indinavir, is it possible?

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