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Treatment after Needle Stick
Aug 6, 1997

What are the sero-conversion statistics for a person exposed to HIV via a needle stick and then treated with Retrovir, Crixivan, and Epivir. If you have any additional information..or resources it would be appreciated.

Response from Dr. Cohen

There are no such statistics. The only data on preventing occupational transmission with antiretrovirals come from a study that suggested that there was an 80% reduction in the risk of seroconversion if you take AZT shortly after a needle stick. The suggestion that combination therapy should be used is not based on solid data, but simply on the fact that combination therapy is stronger and more likely to be effective if the source patient had AZT resistance.



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