nukes non-nukes and tides
May 28, 2001
Can you explain, in simple terms, the differences between nukes, non-nukes, and nucleotide reverse transcriptase inhibitors and the mechanisms they use to stop viral replication?
Response from Dr. Young
HIV reverse transcriptase is the viral enzyme that is largely responsible for replication of the viral genes. There are three different classes of medications that inhibit the HIV reverse transcriptase.
Nucleoside RT inhibitors (nukes) are the largest class of drugs (ZDV, 3TC, d4T, ddI, ddC, abacavir). These drugs have to be activated before they can inhibit the virus. Cellular enzymes convert the drugs into a phosphorylated form called nucleotides. One investigational drug, tenofovir, comes as a phosphorylated form and as such is a nucleotide. These drugs compete with the natural substrate of RT (naturally occuring nucleotides) for binding to the active site of RT and when incorporated into the growing viral genome, prevent further addition of nucleotides.
Non-nucleosides (delaviradine, efavirenz, nevirapine) bind to a site in RT that is separate from the nukes and nucleotides. They inhibit the enzyme in a non-competitive fashion, since they don't compete with a natural substrate. By binding, the non-nukes alter the behavior of the RT, inhibiting it's normal replication function.
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Can I Take Amoxicillin For Vaginal Infections?
- Can Vaginal Prolapse Cause Low Back Pain?
- How Effective Are Swabs When Testing For An Std?
- How Long Does The Hepatitis A Vaccine Work?
- Is It Possible To Have Sores On You Private Part Without It Being An Std?
- Are Painful Swollen Lymph Nodes In Back Of Head Sign Of HIV?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.