The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

mono theraphy
Apr 14, 2001

What are your thoughts on mono theraphy?

Response from Dr. Young

In general terms, I'm not a fan of monotherapy with our current HIV drugs. This statement is based on many early clinical trials that showed the inferiority of monotherapy compared with dual- or triple therapies. A big concern (and clinical managment nightmare) for me is the fallout of monotherapy- largely drug resistance to the drug used, moreover the likelihood that resistance to the first agent used will cause cross resistance to other (or all) other drugs of the same class. This statment is especially true for non-nukes and protease inhibitors.

There is one special circumstance where we have used monotherapy in our clinic- this is the situation of the patient with multi-drug resistant virus- in persons who have been on all available drugs with poor tolerance of combination (or mega-HAART) regimens. In select cases, we have used single drug therapies in the hopes of modest reductions in viral loads with minimal side effects. This strategy is done in the hopes of delaying disease progression until better tolerated and more potent regimens might be available (at which time monotherapy would be abandoned for combination therapy). BY

which treatment to choose

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint