crixivan vs kaletra lipodystopy
Apr 6, 2001
Dear good Doctor I was on crixivan and combivir for 4 1/5 years with mild lipodystrophy, would the lipodystrophy become worst if I witch to kaletra?? thanks
Response from Dr. Young
Thanks for your question.
There is very little information about the differences between indinavir and lopinavir/r (Kaletra) with regards to risk of lipodystrophy. It is very important to remember that despite initial reports that blamed lipodystrophy on proteases ("protease paunch" or "Crix belly") the best available data points to many factors being related to lipodystrophy- age, body mass changes; time since or lowest ever CD4 count; time since highest viral load. Time on therapy is also correlated with risk, however, as you can see, time on therapy would also probably increase the likelihood of having a long time pass between lowest ever CD4 count.
Indeed, one important study (HOPS) showed that if one did not have these non-drug factors, no cases of severe lipodystrophy were seen, even in the face of long-term use of ARV drugs, particularly those that have been implicated in other studies (d4T and indinavir).
In the end, I think that my advice is to stay on successful therapy, unless there is a strong reason to switch (usually side effects or toxicities). The available data on protease inhibitor switches and lipodystrophy fail to show any significant benefit (despite multiple studies).
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Can You Get Hepatitis From Fecal Matter?
- It Is Rare For An Hiv Negative Man To Get Hiv From Vaginal Sex
- Does A Girl Get Hiv Or Aids When She Gets Raped?
- What Type Of Specialist To See Regarding Shingles?
- What Are The Chances Of Transmitting Chlamydia After One Time?
- What Antibiotics Do For Peoples With Herpes?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.