My doctor had me on 800crixivan bid, 300norvir bid, 3tc bid. My last VL 322 cd4 229. He said we could know lower the dose of crixivan down to 800 once a day because of the effects of norvir on crixivan in recent studies. Does this sound reasonable.

It is not totally unreasonable. There is one study I know of suggesting that combining once norvir with crixivan once daily might maintain good crix levels through 24 hours. But, couple of major "buts"

It was a very preliminary study and needs a lot more data. There are no data on whether it maintains good viral suppression. You already have two medications that are twice a day, so what do you gain by taking once a day crix? Your viral load is dropping, but has not yet gotten below 50, so this might not be the best time to modify your regimen. In general, I prefer to use doses and combinations for which we have good information, when possible. Great results so far though, so keep up the good work.

ATP