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Dec 9, 1999

Hi doctor,

I've been into Crixivan(400mg/8 hours) and 3TC+d4T(12hours)for a year. My viral load becames below 40 copies by PCR and T4 about 850 since I started this triterapie. I had not yet any serious side efect, like kidney stones(even if I had some light pain) and a very mild lipodistrophy. Now, my doctor sugests me to keep into 3TC+D4T, twice a day, and Crixivan(400mg)+Norvir(100mg), twice a day and together with meal. I'm a bit worry becuase all people into Norvir takes more than 100mg, even if every 12 hours and while into Crixivan alone I couldn't eat two hours before or one hour after take it. My doctor told me he's adding Norvir to my prior regimen and changing times for Crixivan because it makes easier to manage my time and prevent side efects like kidney stones, but I feel a bit confuse yet and I'd like to know about this treatment he proposed me.... Thanks a lot...


Response from Dr. Pavia


There are some advantages to combining Crixivan with Norvir, and you may want to consider it. When crixivan and norvir are taken together, you only need to take them twice a day and you can eat any time you like. There may be fewer kidney stones, but that has not been proven. If you are doing well, you don't have to change.

Your doctor may be confused as to the doses though. The combinations that have been studied are:

Norvir 100 mg, Crixivan 800 mg (twice a day) Norvir 200 mg, Crixivan 800 mg (twice a day) Norvir 400 mg, Crixivan 400 mg (twice a day)

We have not compared them. I like the Norvir 200, Crixivan 800, or the 100/800 for most people. Good luck ATP

concerned about,RNA Viral LOAD and CD4 COUNT

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