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POST-EXPOSURE treatment in needle-stick injuries of a HIV+ Patient.
Dec 22, 1999

What is a POST-EXPOSURE Treatment in Sero positive needle stick injuriy? and what are the chances of getting infected and what is the success of Anti-retroviral Therapy?

Response from Dr. Pavia

There is great, complete information available at the CDC web site at http://www.cdc.gov/epo/mmwr/preview/mmwrhtml/00052722.htm

The quick answer to your questions is that post exposure prophylaxis is the use of antiviral drugs rapidly after a high risk needle stick (ideally within a few hours) to prevent the person who was stuck from getting infected. The risk depends on characteristics of the stick (worse if it is deep, a hollow needle, and has visible blood; less if it is through gloves) and the characteristics of the HIV infected source patient. The risk is higher if the patient has late stage AIDS or has a high viral load. The overall risk is about 1 in 300 to 400 sticks. The only good estimate we have from one study, suggests that prophylaxis is 80% effective. Other wise stated, it reduces the risk to about 1/5 of what it would be otherwise.

The guidlelines fill in a lot of the other details ATP



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