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Experimental New Drug

Jan 15, 2001

I have been watching for new approaches to combat HIV/AIDS. I came across a drug that has been in pre-clinical development for some time now. Is it possible for the good Doctors to check out this website ( and offer an opinion on the merits of this drug in particular and this technology in general ?? Also, allowing for clinical trials, how long would it take for a drug like this to go from FDA IND acceptance to marketplace ??

Thank you in advance......

Response from Dr. Pavia

I checked out the web site, and have to say I did not learn much. I think the site is aimed at the investors, rather than scientists. Reticulose, or product R, is felt to be an immunomodulator, which can regulate the immune response. Phase 1 studies have not begun in the United States but a phase 1 study is said to be underway in Brazil. It is likely to be 2-3 years before we see clear data to help suggest an effect and another 2-3 years would be needed for Phase 3 studies.

The likelihood that modulating the immune system will be a part of HIV treatment in the future is, in my opinion, very high. However, we have a long way to go developing agents which do this and in understanding them.


Andrew T. Pavia, M.D.

Concerned about a 53 viral load
Treatment Interruption

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