Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: Expert Opinions on HIV Cure Research
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


Twice a day Viracept
Feb 5, 1998

I just read that Argouron announced at the Chicago Retrovirus Conference that Viracept can indeed be given bid. Would you recommend to your patients to immediately start the twice a day dosage at 1125mg (4.5 tabs)? It was also reported that the new dosing will cost $500/year more. Aren't the shareholders getting big enough dividends?

Response from Dr. Gallant

The results presented in Chicago by the European Nelfinavir Clinical Trial Group were interim results of an ongoing trial, but they were encouraging. They compared twice daily and three times daily doses of Viracept in combination with d4T/3TC in 241 patients. Originally there were three different twice-daily dose arms, but as of November, all the patients were getting either standard dose Viracept or 5 tabs (1250 mg) twice a day.

The results, in terms of viral load reduction, were similar between the two groups, with about 80% becoming undetectable by the standard assay (

Keep in mind that these are preliminary results (33 weeks) of a long-term trial that should be continuing for at least 96 weeks. Nevertheless, the viral load data combined with what we know about the half-life of this drug, certainly suggest that twice-daily is probably going to be the way to go.

I'll be talking this over with my patients--at this point I'd probably feel comfortable letting them switch to twice daily dosing, either at 4.5 or 5 tabs twice a day. I don't know the details on the pricing decision, and won't attempt to speak for Agouron!

JG



Previous
Why does Viracept cause Diarrhea?
Next
2X DOSING Viracept

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement