Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


Crixivan Dosage - 2x3 a Days or 3x2 a Day?
Feb 11, 1998

Dear Dr. Gallant:

I recently read in a New York Times article (Friday, February 6, 1998) that Merck has reported a similar level of efficacy in a modified dosage of three 400 mg. capsules of Crixivan twice a day vs. two 400 mg. capsules three times a day. Is there anything to this? I would prefer to take my meds on schedule, and, ideally, together -- thus avoiding the "missed" dosages that occur when I mistime one or the other. I'm currently taking Zerit and Epivir in addition to Crixivan.

On another note, literature I've received from Merck states that hair loss, severe skin reactions and other side effects have been reported as part of their post-marketing experience. I'm curious if the new anti-baldness drug Propecia (also made by Merck) is worthwhile investigating to offset the rather humiliating, although hardly "life-threatening," side effect of hair loss. I have to admit being a bit chagrined by the added insult to injury (never mind the attendant skin problems) of Crixivan-induced hair loss. I will freely admit, however, that I'd rather lose some hair and bit of self-esteem than CD4 cells or risk increasing my viral load because of a perceived loss of attractiveness.

As a closing note, I think the service you provide is exemplary as well as comforting for the many sufferers of HIV. Please keep up the good and worthy work, Dr. Gallant. You certainly live up to your name.

Sincerely,

"Short of Hair but Not Hope" in Washington, D.C.

Response from Dr. Gallant

Well thanks! It's true that there's growing evidence to support twice daily dosing of Crixivan. However, the trial this is based on is a small one. There's a much larger trial in progress, which is more akin to the one that was recently reported regarding twice-daily dosing of Viracept; however, we don't have any results yet.

Given that the half-life of Crixivan is shorter than Viracept, and that the twice-daily dosing trial of Crixivan is smaller and less definitive than the Viracept trial, I think it would be prudent to wait for more results before changing the way you dose your Crixivan.

I'm afraid I can't really comment on Propecia-- it's very new and I don't have enough information about drug interactions. JG



Previous
Dosage of Fortovase when used with Ritonavir
Next
Crix more diabetogen than other PI's?

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement