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diabetes question
Apr 8, 1998

Dear Dr. Currier,

The person asking about diabetes and HIV treatment on April 6th indicated he's taking six capsules of norvir and two capsules of saquinavir twice a day. The standard dosage is 400mg.norvir (4 capsules) and 400mg saquinavir twice a day . Is he taking an excessive dose of norvir? maria.

Response from Dr. Currier

Dear Maria-

I noted that as well. I would say that the most commonly used dose in 400 mg of norvir and 400 mg of saquinavir. Higher doses of norvir, up to 600 mg have been studied and appear effective but with more side effects. When ritonavir is used without saquinavir the dose is 600 mg twice daily. Some people chose to use the higher dose. Whether the higher dose also is more likely to cause or make diabetes worse is not known. Good point- thanks for writing back.

-JC



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