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HIV RNA and HIV ANTIBODY
Oct 31, 2008

hi doctor, 1. recent diagnostic reports of a previously diagnosed (4 years back) confirm hiv+ patient are as follows:

a. "hiv rna detection by rt pcr is negative". the test is done 5 times with an interval of 30 days each. b."hiv antibody reduces from >4 to 0.204" when cut off value is 0.122 c. CD4 cell count raised from 55 to 374.

what is your comment in this case plz?

hypothetically just consider that the patients has got cured. what are the tests needed to confirm his 100% cure.

please doctor, don't ignore this question.

best wishes

Response from Dr. McGowan

One possible explanation is an acute HIV infection with a non-B subtype strain that is not being measured effectively with the RNA PCR test. A drop and recovery in CD4 might be expected in that case. A dDNA assay may be used to amplify a non-B subtype more effectively. This pattern would also be seen in a person taking effective antiretroviral therapy with Immune reconstitution.

Joe


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