|do my meds enter the brain
Jun 30, 2008
Hi Dr. McGownan, I am taking the following meds;prezista,issentriss,intellence,truvada and norvir-I have cogitive deficits-do any of my medications penetrate the brain-my VL<50, T-cells 504. Thankyou
Response from Dr. McGowan
The relationship between penetration of HIV drugs into the central nervous system (including the brain) and risk of either developing central nervous system disease or reversing existing cognitive deficits has not been clearly and definitively established. Your medication regimen is one usually prescribed to someone who is treatment experienced. I am very glad that your viral load is < 50 and your CD4 count is above 500. I would not alter your current regimen and, for example, substitute your prezista with indinavir because indinivar achieves better central nervous system penetration than prezista. In other words, achieving better CNS penetration of a drug your virus may have developed resistance to is not a strategy that I would advocate. The most important goal is to select a regimen that is going to achieve durable viral suppression. If one is fully susceptible to drug A and drug B and drug A has better CNS penetration compared with drug B, I might consider drug A over drug B all other things being equal.
trouble with meds
- Do Night Sweats Mean I Have Hiv?
- Is Fever A Symptom Of Acute HIV Infection?
- Is Groin Pain A Symptom Of Acute HIV Infection?
- Is Painful Urination An Acute Symptom Of HIV?
- Flaky Skin After Oral Sex With No Protection Does It Mean I Have HIV
- Muscle Ache After Anal Sex Bottom Sign Of HIV AIDS
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.